陈晓博士

304浏览器永利集团“杰出中青年学者”教授，博士生导师

国家海外高层次人才，山东省海外科技人才

教师主页：https://faculty.sdu.edu.cn/xc

电子邮箱：xc@sdu.edu.cn

工作地点：304浏览器永利集团（威海）304浏览器永利集团628室

工作经历

2024/01至今教授，杰出中青年学者·304浏览器永利集团·304浏览器永利集团

2022/01-2023/12研究员，齐鲁青年学者·304浏览器永利集团·304浏览器永利集团

2021/04 - 2021/09副研究科学家（Associate Research Scientist）·美国哥伦比亚大学·遗传发育系

2018/04 - 2021/04博士后研究员·美国哥伦比亚大学·遗传发育系

教育经历

2016/10 - 2017/09国家公派联合培养博士·美国密歇根大学·医学院

2012/09 - 2018/01理学博士·中国海洋大学·海洋生物多样性与进化研究所

2008/09 - 2012/07理学学士·中国海洋大学·生物科学

研究方向

真核生物内稳态的表观遗传调控

主持项目

2024/01-2026/12国家海外高层次人才项目，主持

2024/01 - 2028/12304浏览器永利集团“杰出中青年学者”人才项目，主持

2023/01 - 2026/12国家自然科学基金面上项目，主持

2023/01 - 2025/12山东省高等学校青创科技支持计划，主持

2022/07 - 2025/06江苏省自然科学基金青年科学基金项目，主持

2022/01 - 2027/01304浏览器永利集团“齐鲁青年学者”人才项目，主持

获奖荣誉

2023年国家海外高层次人才

2023年入围首届“海洋强国青年科学家”评选

2023年山东省海外科技人才

2023年304浏览器永利集团“杰出中青年学者”

2022年青岛市科学技术奖自然科学奖一等奖

2022年304浏览器永利集团“齐鲁青年学者”

2019年山东省优秀博士毕业论文

2017年国际原生生物学家学会“Holz-Conner”奖

讲授课程

2022/09至今讲授研究生课程《专业外语》

学会成员

2017/07至今国际原生生物学家学会（International Society of Protistologists）成员

2019/05 - 2021/09纽约科学院（New York Academy of Sciences）成员

学术成果

发表SCI文章40余篇，累计影响因子600余点，累计引用1500余次。核心成果发表在Nature Communications、PNAS、Molecular Cell、Protein & Cell、Nucleic Acids Research等国际知名刊物上。

代表性工作

1. Xiao Chen, Yinglu Li, Fang Zhu, Xinjing Xu, Brian Estrella, Manuel A. Pazos II, John T. McGuire, Dimitris Karagiannis, Varun Sahu, Mustafo Mustafokulov, Claudio Scuoppo, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano, Laura Pasqualucci, Alberto Ciccia, Jennifer E. Amengual & Chao Lu (2023). Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma.Nature Communications. 14(1), 4259. DOI: 10.1038/s41467-023-39990-5.

2. Yimeng Fang, Vaibhav S. Mangipudy, Chao Lu, Songtao Jia&Xiao Chen(2023). Recognition of Histone Methylation and DNA by PWWP Domain: Mechanism and Function. InChromatin Readers in Health and Disease. Trygve O Tollefsbol, Olivier Binda (eds). Academic Press, New York. ISBN: 9780128233764. (Book chapter)

3. Wen Song, Huixin Jiao, Juan Yang, Danxu Tang, Tingting Ye, Lu Li, Lei Yang, Lifang Li, Weibo Song, Saleh A. Al-Farraj, Hunter N. Hines, Weiwei Liu &Xiao Chen (corresponding author)(2023). New evidence of consistency between phylogeny and morphology for two taxa in ciliated protists, the subclasses Oligotrichia and Choreotrichia (Protista, Ciliophora).Molecular Phylogenetics and Evolution. 188, 107911. DOI: 10.1016/j.ympev.2023.107911.

4. Yinglu Li, Elizabeth M. Goldberg,Xiao Chen(co-first author), Xinjing Xu, John T. McGuire, Giuseppe Leuzzi, Dimitris Karagiannis, Tiffany Tate, Nargess Farhangdoost, Cynthia Horth, Esther Dai, Zhiming Li, Zhiguo Zhang, Benjamin Izar, Jianwen Que, Alberto Ciccia, Jacek Majewski, Angela J. Yoon, Laurie Ailles, Cathy Lee Mendelsohn & Chao Lu (2022). Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.Molecular Cell, 82(20),3901-3918.DOI: 10.1016/j.molcel.2022.09.007.

5. Kartik N. Rajagopalan,XiaoChen (co-first author), Daniel N. Weinberg, Haifen Chen, Jacek Majewski, C. David Allis & Chao Lu (2021). Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.PNAS,118(9), e2021795118. DOI: 10.1073/pnas.2021795118.

6. Xiao Chen, Yaohan Jiang, Feng Gao, Weibo Zheng, Timothy J. Krock, Naomi A. Stover, Chao Lu, Laura A. Katz & Weibo Song (2019). Genome analyses of the new model protistEuplotes vannusfocusing on genome rearrangement and resistance to environmental stressors.Molecular Ecology Resources, 19(5), 1292-1308. DOI: 10.1111/1755-0998.13023.

7. Xiao Chen,Yurui Wang, Yalan Sheng, Alan Warren & Shan Gao (2018). GPSit: an automated method for evolutionary analysis of nonculturable ciliated microeukaryotes.Molecular Ecology Resources, 18(3), 700-713. DOI: 10.1111/1755-0998.12750.

8. Yuanyuan Wang,Xiao Chen (co-first author), Yalan Sheng, Yifan Liu & Shan Gao (2017). N⁶-adenine DNA methylation is associated with H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes inTetrahymena.Nucleic Acids Research, 45(20), 11594-11606. DOI: 10.1093/nar/gkx883.

9. Xiao Chen, Shan Gao, Yifan Liu, Yuanyuan Wang, Yurui Wang & Weibo Song (2016). Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism,Tetrahymena thermophila.Science China Life Sciences, 59(9), 909-919. DOI:10.1007/s11427-016-5102-x.

10. Xiao Chen, Xiaolu Zhao, Xiaohui Liu, Alan Warren, Fangqing Zhao & Miao Miao (2015). Phylogenomics of non-model ciliates based on transcriptomic analyses.Protein & Cell, 6(5), 373-385. DOI: 10.1007/s13238-015-0147-3.