个人简历

姓名：李志华

性别：男

民族：汉

出生日期：1979年6月

籍贯：河北省辛集市

工作单位：304浏览器永利集团  教授 博士生导师

通信地址：山东省威海市文化西路180号

电子邮件:   lizh@sdu.edu.cn

现为304浏览器永利集团 教授，博士生导师，湖北省杰出青年基金获得者，入选武汉市青年科技晨光计划和中国水产科学研究院“百名英才”人才计划，入选2022年度“全球顶尖前10万科学家排名”榜单。博士毕业于捷克南波希米亚大学，长期从事水环境健康与生态风险评估研究。2010年赴美国加州大学河滨分校Prof. Danel Schlenk实验室访问交流。2011年-2012年，在新加坡国立大学从事博后研究。

以第一作者(或通讯)在Journal of Hazardous Materials、Water Research、Environmental Pollution等学术刊物发表87篇（总共发表101篇），文章总被引2667次（他引2474次），H-index=32。目前担任SCI刊物Bulletin of Environmental Contamination and Toxicology的编委和Frontiers in Marine Science，Water，BioMed Research International专刊的客座主编，并担任 Environmental Science & Technology等31种该领域SCI期刊的独立审稿人。申报获得授权专利11项（其中第一发明人8项）。

获得奖励包括：河北省优秀毕业生（2005）；河北省优秀三好学生（2005）；南波西米亚大学渔业与水保护学院35岁以下青年优秀科研成果一等奖（2009）；国家优秀自费留学生奖学金（2010）；南波西米亚大学优秀科技成果校长奖（2011）；首届中国水产青年科技奖（2016年）。

研究兴趣：

（1）气候变化耦合水环境污染的生态效应   采用典型模式物种作为实验模型，将微观与宏观相结合，在多层次水平上采用多组学交叉技术的系统毒理学方法探索气候变化背景下近海及内陆水污染的生态效应及其机制；通过构建室内微宇宙模型系统，探讨水环境污染物在食物链的传递及种群效应；研究气候变化背景下近海碳循环及碳固定机制，为我国发展“双碳”战略、生态安全等决策提供理论依据。

（2）水环境健康与生态风险评估 主要针对水环境中新兴污染物的时空分布、来源、归趋、降解等环境行为进行调查分析，进一步结合室内模型评估其环境风险及并开发修复技术；筛选并验证典型污染物的有效的分子生物标记物，发展环境污染的早期预警系统，以便为污染物的环境健康风险评估及治理提供科学依据。

（3）近岸养殖生态与生境调控 主要针对近岸养殖生态、生境调控以及生物-生境相关性开展工作，通过微生物组学结合环境因子综合分析，揭示微环境多层次复杂系统调控机制，为我国蓝色粮仓产业健康发展提供技术支撑。

近期主持课题情况：

· 2023-2026，基于海水青鳉模型研究环境水平三苯基锡多代神经行为毒性效应及其机制（国家自然科学基金，42277269）

· 2021-2022，不同盐度下三苯基锡胁迫海水青鳉的系统毒理学研究（城市水资源与水环境国家重点实验室开放课题-重点项目（哈尔滨工业大学），ESK202103）

· 2021-2023，盐度变化对南海近海三苯基锡生态效应影响的系统毒理学评价（热带海洋环境国家重点实验室（中国科学院南海海洋研究所），LTO2119）

· 2018-2023, 项目“我国重要渔业水域食物网结构特征与生物资源补充机制”-课题“重要渔业种群动态长期变化特征及生态适应性”-子课题“草鱼鲢鱼面对环境污染物变化时的繁殖生物学适应及内在分子机制”（国家重点研发计划“蓝色粮仓科技创新”专项，2018YFD0900902，2019/01-2023/12，子课题负责人）

· 2018-2020，环境激素三丁基锡的分子毒理学及生物标志物筛选（湖北省自然科学基金杰出青年项目，2017CFA071）

· 2017-2019，环境激素三苯基锡内分泌干扰跨代效应研究（武汉市青年科技晨光计划，2017050304010273）

· 2016-2019，低剂量三丁基锡与镉联合暴露对鲤鱼内分泌轴线交互影响效应及作用机制研究（国家自然科学基金，31570511）

· 2015-2019，典型化学物污染淡水水产品质量安全综合防治技术方案（课题共同负责人）（公益性行业（农业）科研专项经费项目，201503108-CC-1）

· 2015-2017，温度对草鱼幼鱼在低剂量汞胁迫下毒代动力学及生理应答影响研究（国家自然科学基金，21407181）

· 2015-2016，不同温度下草鱼幼鱼对汞胁迫的耐受性研究（湖北省自然科学基金面上项目，2014CFB266）

学术兼职

· SCI刊物编辑：Bulletin of Environmental Contamination and Toxicology

· SCI刊物特约主编：Frontiers in Marine Science专刊“Influences of Climate Change Coupled with Aquatic Pollutions”.

· SCI刊物特约主编：Water专刊“Effects of Emerging Pollutants on Ecological Health in Aquatic Environment”.

· SCI刊物特约主编：BioMed Research International专刊 “Endocrine Toxicology in Aquatic System”、 “Aquatic Environment Health and Toxicology”.

· SCI刊物独立审稿人： Water Research, Journal of Hazardous Materials, Environmental Science & Technology, Environmental Pollution等40余个本领域期刊。

· 中国水产学会青年工作委员会委员，国家自然基金通信评审专家，科技部国际合作专项会评专家，教育部长江学者奖励计划通信评审专家，科技部创新人才推进计划通信评审专家，中国水产科学研究院渔业生态学科学术委员以及广东湖北贵州浙江等省科技项目评审专家等。

发表SCI文章情况

近三年发表SCI论文40余篇，其中JCR一区论文30余篇，主要发表在Environmental Pollution、Chemosphere、Aquatic Toxicology、Aquaculture等国际知名期刊。

1. Zhang, S.Q.¹, Li, P.¹, He, S.W., Xing, S.Y., Cao, Z.H., Zhao, X.L., Sun, C.C., Li, Z.H.* 2023. Assessing the ecotoxicity of combined exposure to triphenyltin and norfloxacin at environmental levels: a case study of immunotoxicity and metabolic regulation in Carp (Cyprinus carpio). Chemosphere, 313,137381.

2. Wang, X.¹, Li, P.¹, Cao, X.Q., Liu, B., He, S.W., Cao, Z.H., Xing, S.Y., Liu, L., Li, Z.H.* 2022. Effects of ocean acidification and tralopyril on bivalve biomineralization and carbon cycling: a study of the Pacific Oyster (Crassostrea gigas)   Environmental Pollution, 313, 120161.

3. Xing, S.Y.¹, Li, P. ¹, He, S.W., Cao, Z.H., Wang X., Cao, X.Q., Liu, B., You, H., Li, Z.H.* 2022. Physiological responses in Nile tilapia (Oreochromis niloticus) induced by combined stress of environmental salinity and triphenyltin. Marine Environmental Research, 180, 105736.

4. Chen, C.Z., Li, P., Liu, L., Li, Z.H.* 2022. Exploring the interactions between the gut microbiome and the shifting surrounding aquatic environment in fisheries and aquaculture: A review. Environmental Research, 214, 114202.

5. He, S.W., Yu, D.D., Li, P., Zhang, M., Xing, S.Y., Liu, B., Sun, C.C, Liu, L., Li, Z.H.* 2022. A new perspective on endocrine disrupting effects of triphenyltin on marine medaka: From brain transcriptome, gut content metabolome and behaviour. Chemosphere, 307, 136190.

6. Ru, J.C., Zhao, X.L., Cao, Z.H., Chen, C.Z., Li, P.*, Li, Z.H.* 2022. Chronic toxic effects of polystyrene micro-plastics, DCOIT and their combination on Marine Chlorella sp. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 261, 109426.

7. Zhao, X.L.¹, Li, P.¹, Qu, C.F., Lu, R.*, Li, Z.H.* 2022. Phytotoxicity of environmental norfloxacin concentrations on the aquatic plant Spirodela polyrrhiza: evaluation of growth parameters, photosynthetic toxicity and biochemical traits. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 258, 109365.

8. Wang, Y.J.¹, Chen, C.Z.¹, Li, P., Liu, L., Chai, Y.*, Li, Z.H.* 2022. Chronic toxic effects of waterborne mercury on Silver carp (Hypophthalmichthys molitrix) larvae. Water, 14, 1774.

9. Cao, X.Q., He, S.W., Liu, B., Wang, X., Xing, S.Y., Cao, Z.H., Chen, C.Z., Li, P.,* Li, Z.H.* 2022. Exposure to enrofloxacin and depuration: Endocrine disrupting effect in juvenile grass carp (Ctenopharyngodon idella), Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 257, 109358.

10. Liu, B.¹, Li, P.¹, He, S.W., Xing, S.Y., Liu, L., Li, Z.H.* 2022. Chronic exposure to Tralopyril induced abnormal growth and calcium regulation of turbot (Scophthalmus maximus), Chemosphere, 299, 134405.

11. Chen, C.Z¹., Li, P¹., Liu, L., Li, Z.H.* 2022. Transcriptomic and proteomic analysis of Chinese rare minnow (Gobiocypris rarus) larvae in response to acute waterborne cadmium or mercury stress. Aquatic Toxicology, 246, 106134.

12. Xing, S.Y.¹, Li, Z.H.¹, Li, P., You, H.* 2022. A mini-review of the toxicity of pollutants to fish under different salinities. Bulletin of Environmental Contamination and Toxicology, 108, 1001-1005.

13. Zhang, S.Q.¹, Zhao, X.L.¹, He, S.W., Xing, S.Y., Cao, Z.H., Li, P.*, Li, Z.H.* 2022. Effects of long-term exposure of norfloxacin on the the HPG and HPT axes in juvenile common carp. Environmental Science and Pollution Research, 29, 44513-44522.

14. Liu, B.¹, Li, P.¹, He, S.W., Xing, S.Y., Cao, Z.H., Cao, X.Q., Wang, X., Li, Z.H.* 2022. Effects of short-term exposure to tralopyril on physiological indexes and endocrine function in turbot (Scophthalmus maximus), Aquatic Toxicology, 245, 106118.

15. Cao, Z.H.¹, Li, P.¹, Cao, X.Q., Wang, X., Liu, B., He, S.W., Gao, G., Lu, R.*, Li, Z.H.* 2022. Reproductive toxicity of environmental levels of triphenyltin to the marine rotifer, Brachionus plicatilis. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 254, 109272.

16. Chen, C.Z¹., Li, P¹., Wang, W.B.*, Li, Z.H.* 2022. Response of growth performance, serum biochemical parameters, antioxidant capacity, and digestive enzyme activity to different feeding strategies in common carp (Cyprinus carpio) under high-temperature stress. Aquaculture, 548, 737636.

17. Wang, X.¹, Li, P.¹, He, S.W., Xing, S.Y., Cao, Z.H., Liu, B., Li, Z.H.* 2022. Effects of tralopyril on histological, biochemical and molecular impacts in Pacific oyster, Crassostrea gigas. Chemosphere, 289, 133157.

18. Cao, Z.H.¹, Li, P.¹, Ru, J.C., Cao, X.Q., Wang, X., Liu, B., Li, Z.H.* Physiological responses of marine Chlorella sp. exposed to environmental levels of triphenyltin.  Environmental Science and Pollution Research, accepted.

19. Ru, J.C., Zhao, X.L., Cao, Z.H., Chen, C.Z., Li, P.*, Li, Z.H.* 2022. Acute toxicity of a novel anti-fouling material additive DCOIT to Marine Chlorella sp. Bulletin of Environmental Contamination and Toxicology, accepted.

20. He, S.W.¹, Li, P.¹, Liu, L., Li, Z.H.* 2022. NMR technique revealed the metabolic interference mechanism of the combined exposure to cadmium and tributyltin in grass carp larvae. Environmental Science and Pollution Research, accepted.

21. Cao, Z.H., Li, P.*, Li, Z.H.* 2021.A latest review on the application of microcosm model in environmental research. Environmental Science and Pollution Research, 28, 60438–60447.

22. He, S.W., Yu, D.D., Li, P., Zhang, M., Xing, S.Y., Sun, C.C, Li, Z.H.* 2021. Triphenyltin exposure causes changes in the health-associated gut microbiome and metabolites in marine medaka. Environmental Pollution, 288, 117751.

23. Zhang, S.Q.¹, Li, P.¹, Zhao, X.L., He, S.W., Xing, S.Y., Cao, Z.H., Zhang, H.Q.*, Li, Z.H.* 2021. Hepatotoxicity in carp (Cyprinus carpio) exposed to environmental levels of norfloxacin (NOR): Some latest evidences from transcriptomics analysis, biochemical parameters and histopathological changes. Chemosphere, 283, 131210.

24. Zhao, X.L.¹, Li, P.¹, Zhang, S.Q., He, S.W., Xing, S.Y., Cao, Z.H., Lu, R., Li, Z.H.* 2021. Effects of environmental norfloxacin concentrations on the intestinal health and function of juvenile common carp and potential risk to humans. Environmental Pollution, 287, 117612.

25. Li Z.H*., Li P.*, Wu Y.H. 2021. Effects of temperature fluctuation on endocrine disturbance of grass carp Ctenopharyngodon idella under mercury chloride stress. Chemosphere, 263, 128137.

26. Li, Z.H.*, Li, P*. 2021. Effects of the tributyltin on the blood parameters, immune responses and thyroid hormone system in zebrafish. Environmental Pollution, 268, 115707.

27. Li Z.H*., Li P.*, Wu Y.H. 2021. Regulation of glutathione-dependent antioxidant defense system of fish Ctenopharyngodon idella under the combined stress of mercury and temperature. Environmental Science and Pollution Research, 28, 1689–1696.

28. He, S.W., Li, P., Li, Z.H.*. 2021. Review on endocrine disrupting toxicity of triphenyltin from the perspective of species evolution: Aquatic, amphibious and mammalian. Chemosphere, 269, 128711.

29. Zhang, S.Q., Li, P., Li, Z.H.* 2021.Toxicity of organotin compounds and the ecological risk of organic tin with co-existing contaminants in aquatic organisms. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 246, 109054.

30. Li, Z.H., Li, Z.P., Tang, X., Hou, W.H., Li, P*. 2021. Distribution and risk assessment of toxic pollutants in surface water of the lower Yellow river, China. Water, 13, 1582.

31. Li, P., Li, Z.H.*. 2021. Neurotoxicity and physiological stress in brain of zebrafish chronically exposed to tributyltin. Journal of Toxicology and Environmental Health, Part A Current Issues, 84, 20-30.

32. Li P., Li Z.H.*, Wu Y.H. 2021. Interactive effects of temperature and mercury exposure on the stress-related responses in the freshwater fish Ctenopharyngodon idella. Aquaculture Research. 52, 2070–2077.

33. Li Z.H.*, Li P., Wu Y.H. 2021. Effects of waterborne mercury at different temperature on hematology and energy metabolism in grass carp (Ctenopharyngodon idella). International Journal of Environmental Science and Technology, 18, 1489–1498.

34. Li, P., Li, Z.H.*. 2020. Tributyltin induces the tissue-specific stresses in zebrafish, a study in various tissues of muscle, gill and intestine. Bulletin of Environmental Contamination and Toxicology, 105, 847–852.

35. Li, P., Li, Z.H.*. 2020. Toxicity evaluation of triphenyltin in zebrafish larvae by embryonic malformation, retinal development, and GH/IGF axis. Fish Physiology and Biochemistry, 46, 2101-2107

36. Li, P., Li, Z.H.*. 2020. Environmental co-exposure to TBT and Cd caused neurotoxicity and thyroid endocrine disruption in zebrafish, a three-generation study in a simulated environment. Environmental Pollution, 259,113868.

37. Li, P., Li, Z.H.*, Zhong L.Q. 2020. Parental exposure to triphenyltin inhibits growth and disrupts thyroid function in zebrafish larvae. Chemosphere, 240,124936.

38. Li, P., Li, Z.H.*, Zhong L.Q. 2019. Effects of low concentrations of triphenyltin on neurobehavior and the thyroid endocrine system in zebrafish. Ecotoxicology and Environmental Safety,186,109776.

39. Li, P., Li, Z.H.*, Zhong, L.Q. 2019. Triphenyltin exposure alters the antioxidant system, energy metabolism and the expression of genes related to physiological stress in zebrafish (Danio rerio). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 225, 108581.